From the LSD-sure crystal structure, the side chain of your lid residue L209EL2 types intensive hydrophobic contacts with both LSD and bordering residues in TMs III, IV, and V (Figure 4C). Once the lid moved apart to reveal the binding pocket in simulation, quite a few of these contacts broke. https://riverjonmi.designertoblog.com/66374893/what-does-fractal-storm-self-laid-mean